Table 1.

Phenotypes of the 5-HTR2C deficient mice.

Mice Model	Body Weight	Fat Mass	Lean Mass	Food Intake	Binge-like Eating	Hepatic Glucose Production	Reference
2C-null	↑	↑	↓	↑	↓	↑	(5, 25)
POMC-2C-null	↑	↑	↓	↑	↓	↑	(15)
POMC-2C-RE	↔	↔	↔	↔	/	↔	(25)
DA-2C-RE	/	/	/	↑	↔	/	(15)
DA-2C-KO	/	/	/	↑	↓	/	(15)

‘↑’, Increased; ‘↓’, Reduced; ‘↔’, No change; ‘/’, Unknown. 2C-null is a loxed transcription blocker (loxTB) 5-HTR2C mouse line lacking functional 5-HTR2C globally; POMC-2C-null mice with previously characterized animals in which cre is constitutively (developmentally) expressed in POMC neurons to ablate 5-HTR2C specifically; POMC-2C-RE mice with 5-HTR2C re-expressed specifically and only in POMC neurons; DA-2C-RE mice with the expression of endogenous 5-HTR2C only in DA neurons; DA-2C-KO with deletion of endogenous 5-HTR2C only in DA neurons.