TABLE 2.
The comparison of the fertilization rates using different methods.
| ICSI | Conventional ICSI-AOA | Novel ICSI-AOA | p-value | |
| Case 1 | 1/15 (6.7%)a | 0/19 (0.0%)b | 7/16 (43.8%)a b | 0.001* |
| Case 2 | 0/6 (0.0%)a | 1/10 (10.0%)b | 4/7 (57.1%)a b | 0.033* |
| Case 3 | 0/8 (6.7%) | 1/7 (14.3%) | 1/8 (12.5%) | 0.747 |
| Case 4 | 1/10 (10.0%) | 0/7 (0.0%)a | 8/18 (44.4%)a | 0.034* |
| Case 5 | 0/9 (0.0%)a | 1/7 (14.3%) | 7/12 (58.3%)a | 0.010* |
| Case 6 | 0/7 (0.0%) | 0/7 (0.0%) | 1/2 (50.0%)1 | 0.056 |
Data were shown in number of fertilization oocytes/number of MII oocytes (percentage). Conventional ICSI-AOA: Ca2+-ionophore A23187 only. Novel ICSI-AOA: A combination of cycloheximide and ionomycin. 1The oocytes for novel ICSI-AOA were frozen-thawed oocytes from the affected female patient. a bThere were statistical differences between the groups labeled with the same letter. *p-values < 0.05 were considered to be statistically significant.