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. 2021 Jul 21;9:702579. doi: 10.3389/fcell.2021.702579

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Copyright © 2021 Ju, Liu, Ouyang, Liu, He and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global m⁶A modification changes in DCM hearts compared with control heart tissue. (A) Identification of 106 hyper-methylated and 190 hypo-methylated m⁶A peaks that were significantly increased or decreased (fold-change > 2, P < 0.05) in abundance, respectively, in the DCM compared with NC samples. (B) m⁶A abundance in Zfp69 and Pkp4 mRNA transcripts in the NC and DCM samples, as detected by m⁶A-seq; m⁶A peaks in green rectangles showed significantly increased or decreased abundance (fold-change > 2, P < 0.05) in the DCM compared with NC samples. (C–F) Gene ontology enrichment and pathway analyses of differentially altered m⁶A mRNA in DCM compared with NC groups; top 10 significantly enriched pathways for upregulated (C) and downregulated (D) genes; major gene ontology terms significantly enriched for up-methylated (E) and down-methylated (F) genes. ARS pathway involved in diabetic complications: AGE-RAGE signaling.