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. 2021 Jul 21;9:702579. doi: 10.3389/fcell.2021.702579

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Copyright © 2021 Ju, Liu, Ouyang, Liu, He and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reconstitution of FTO alleviated cardiac hypertrophy and fibrosis in diabetic db/db mice. (A) The gross morphology of hearts stained with HE, Masson, and WGA. Scale bar, 2 mm (B,C) Quantitative analysis of interstitial fibrosis and cardiomyocyte cross-sectional area. Scale bar, 20 μm. Mice with reconstituted FTO showed significantly increased ejection fraction (D), fractional shortening (E), and E/A ratio (F). Mice with reconstituted FTO showed reduced Cd36 (G) and Bcl2l2 (H) expression, as determined by qPCR. Data are expressed as mean ± SD and were analyzed using the Student’s t-test. *P < 0.05; **P < 0.01, ****P < 0.0001 vs. NC group (n = 3 per group).