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. 2021 Jul 21;8:703715. doi: 10.3389/fmolb.2021.703715

FIGURE 2.

FIGURE 2

Peptide inhibitors of ADAMTS proteins. (A) Aminoacidic sequence of linear peptide 2 derived from the C-terminus TSP-1 motif of aggrecanase-1; (B) Chemical structure of B05-derived linear peptide 4 (KHN(e)FRQRETYMVFKGK); (C) Chemical structure of B06-derived linear peptide 3 (DVQ(e)FRGVTAVIR); (D) Chemical structure of cyclic peptide 62CASESLC68; (E) Chemical structure of cyclic peptide 60CTEASESLAGC70; (F) Chemical structure of cyclic peptide 61CEASESLAGC70; (G) Aminoacidic sequence of linear peptide VWF-73 peptide (Met1606-Arg166) derived from C-terminal region of the multimeric von Willebrand factor (VWF); (H) Aminoacidic sequence of linear peptide epitope-A (PP-a); (I) Aminoacidic sequence of linear peptide epitope-B (PP-b); (L) Aminoacidic sequence of polycyclic human neutrophil peptide 1 (HNP-1); (M) Aminoacidic sequence of polycyclic human neutrophil peptide (HNP-2). Indicated half maximal inhibitory concentration (IC50), inhibition constant (K i) and dissociation constant (K d) values were reported as published. The targeted ADAMTS protein is reported near the IC50, K i, or K d value.