Table 2.
LncRNAs regulating apoptosis in lung cancer.
| LncRNA | Sample | Cell line | Target/Pathway | Function | Ref |
|---|---|---|---|---|---|
| FER1L4 | Human | – | PTEN, AKT, p53, Ki67, PCNA, MMP2/9, Bcl-2, Bax, Caspase-3/9 | FER1L4 through the PTEN/AKT/p53 signaling pathway could promote cell apoptosis in NSCLC. | (58) |
| PCAT1 | Rat | BEAS-2B, A549, A427, H460 | VEGF, AKT, Bcl-2, Vimentin, N-cadherin, Caspase-3/8/9/12, DKC1, PARP, Cyclin-D, E-cadherin | PCAT1 through the VEGF/AKT/Bcl2/Caspase-9 pathway could regulate apoptosis in NSCLC cells. | (59) |
| WT1-AS | Human | 16-HBE, A549, NCI-H1975, SK-MES-1 | miR-494-3p, PTEN, PI3K, AKT, Bcl-2, Bax, Caspase-3, CDK2, Cyclin-E1 | WT1-AS/miR-494-3p through the PTEN/PI3K/AKT Signaling Pathway could regulate apoptosis in NSCLC cells. | (60) |
| GACAT1 | Human | NHBE, A549, H1299, H460, SK-MES-1 | YY1, miR-422a | GACAT1 via sponging miR-422a could induce apoptosis in NSCLC cells. | (61) |
| HOXC-AS2 | – | – | – | HOXC-AS2 via combining with the HOXC13 gene could mediate apoptosis in NSCLC. | (62) |
| SNHG1 | Human | BEAS‐2B, H23, H1299 | FRAT1 | SNHG1 through the miR‐361‐3p/FRAT1 axis could influence cell apoptosis in NSCLC. | (63) |
| ASB16-AS1 | Human | 16HBE, A549, NCI-H266, NCI-H1299, SK-MES-1 | p21, β-catenin, Cyclin-D1 | ASB16-AS1 via activating the Wnt/β catenin signaling pathway could promote apoptosis of NSCLC. | (37) |
| PVT1 | Human, mice | BEAS-2B, A549, PC-9, H157, H460 | ITGB8, MEK, ERK | PVT1 via targeting miR-145-5p could regulate cell apoptosis in NSCLC. | (64) |
| LEF1-AS1 | human | NCIH1993, NCI-H1581 | miR-221, PTEN | LEF1-AS1 via regulating miR-221/PTEN Signaling could induce apoptosis in NSCLC. | (65) |
| MALAT1 | Human, mice | BEAS-2B, H460, A549, H661, H358 | miR-374b-5p, SRSF7 | Knockdown of MALAT1 through miR-374b-5p/SRSF7 axis could regulate apoptosis in NSCLC. | (66) |
| MIR503HG | human | BEAS-2B, A549, NCI-H1299, NCI-H1975, NCI-H2170 | Cyclin-D1/E, PCNA, p16, p21, Bcl-2, Bax, Caspase-3/9 | MIR503HG via regulating miR-489-3p and miR-625-5p could promote apoptosis in NSCLC. | (67) |
| NEAT1 | Human | BEAS-2B, A549, H292 | SULF1, MAPK, Akt | NEAT1 via targeting has-miR-376b-3p/SULF1 axis could regulate apoptosis in NSCLC. | (25) |
| NEAT1 | – | A549 | miR-1224, KLF3 | Knockdown of NEAT1 by sponging the miR-1224 could enhance the apoptosis in lung cancer | (68) |
| PRNCR1 | Human | BEAS-2B, SPC-A1, A549 | E-cadherin, N-cadherin, Vimentin, MTDH | Knockdown of PRNCR1 through sponging miR-126-5p could inhibit cell apoptosis in NSCLC treatment. | (69) |
| HCG11 | Human, mice | A549, SPC-A1, H1299, H1650, H1975, PC-9 | Caspase-3 | HCG11 by Sponging miR-224-3p could promote apoptosis in NSCLC. | (70) |
| SNHG6 | Human | BEAS-2B, A549, H460, H1299 | Bcl-2, Bax, Caspase-3, RSF1 | SNHG6 via regulating miR-490-3p/RSF1could inhibit apoptosis in NSCLC. | (71) |
| SNHG7 | Human | BEAS-2B, H125, 95D, A594 | FAIM2 | SNHG7 via enhancing the FAIM2 expression could inhibit apoptosis in LC. | (72) |
| SNHG12 | Human, mice | 16-HBE, H1299, A549, H358, H1975, SPC-A1 | miR-138 | Knockdown of SNHG12 via Upregulating miR-138 could induce apoptosis in NSCLC. | (73) |
| SNHG14 | Human, mice | PC9, PC9/GR | ABCB1, miR-206-3p | Knockdown of SNHG14 by sponging miR-206-3p via upregulating ABCB1 could induce apoptosis in NSCLC. | (13) |
| SNHG20 | Human, mice | A549, H32, H1299, GLC-82, SPC-A1 | ZEB2, RUNX2 | Knockdown of SNHG20 by acting as a miR-154 sponge could promote apoptosis in NSCLC. | (45) |
| Human | 16HBE, A549, H1299 | E2F3, P13k, Akt | Knockdown of SNHG20 via regulating miR-2467-3p/E2F3 could induce apoptosis in NSCLC. | (74) | |
| Human | 16HBE, A549, NCI-H520, H1299 | TCF4, LEF1, Wnt/β-catenin | SNHG20 via Wnt/β-catenin signaling pathway by targeting miR-197 could inhibit the apoptosis of NSCLC cells. | (75) | |
| SNHG20 | Human | 16HEB, A549, H1299 | DDX49, miR-342 | Knockdown of SNHG20 by sponging miR-342 and upregulating DDX49 could promote cell apoptosis in lung adenocarcinoma. | (76) |
| HAND2-AS1 | Human | BEAS-2B, NCI-H23, NCI-H522 | PI3K, Akt | HAND2-AS1 via inactivating PI3K/Akt pathway could promote cell apoptosis in NSCLC. | (77) |
| PANDAR | Human | 16HBE, L78, PC9, 95D, NCI-H460, A549 | Beclin-1, LC3-I, LC3-II | PANDAR by upregulation of BECN1 expression via activating autophagy and apoptosis pathways could inhibit the development of lung cancer. | (14) |
| LINC00460 | Murine | A549 | miR-539 | LINC00460 via targeting miR-539 could inhibit apoptosis in NSCLC. | (78) |
| ATB | – | NCI-H838, BEAS-2B | Bcl-2, Caspase-3, CytC | ATB via suppressing the expression of miR-200a and up-regulating the expression of β-catenin could promote apoptosis in NSCLC. | (79) |
| AWPPH | Human | WI-38, NCI-H23, NCI-H522 | Wnt, β-catenin | AWPPH via activating the Wnt/β−catenin signaling pathway could inhibit apoptosis in NSCLC. | (80) |
| DLX6-AS1 | Human, mice | 16HBE, H1975, A549 | PRR11 | Knockdown of DLX6-AS1 via downregulating PRR11 expression and upregulating miR-144 could promote apoptosis in NSCLC. | (53) |
| BANCR | Human, mice | A549, SPC-A1, H1299, H1650, H1975, PC-9 | Bcl-2, Bax | Overexpression of BANCR could increase apoptotic level. | (81) |
| TSLNC8 | Human | HBE, A549, H441, H1975 | CDK2, Cyclin-E1, p21, MMP9, Bcl-2, Bax, Caspase-3 | TSLNC8 via targeting the IL-6/STAT3/HIF-1α signaling pathway could accelerate apoptosis in NSCLC. | (82) |
| AFAP1-AS1 | Human, mice | BEAS-2B, H1975, PC-9, A549, SPCA-1 | RRM2, EGFR, Akt | AFAP1-AS1 via Competitively upregulating RRM2 by sponging miR-139-5p could reduce apoptosis in NSCLC. | (83) |
| PCAT-1 | Human | 16HBE, H1299, SK‐MES‐1 | PCAT‐1, LRIG2 | Knockdown of PCAT‐1 via regulating miR‐149‐5p/LRIG2 axis could induce apoptosis promotion in NSCLC. | (84) |
| HULC | Human | NCI-H23, NCI-H522 | PI3K, Akt, SPHK1 | HULC via upregulating sphingosine kinase 1(SPHK1) and its downstream PI3K/Akt pathway could inhibit apoptosis in NSCLC. | (85) |
| EPB41L4A-AS2 | Human | 16HBE, SK-MES-1, HCC827, A549, NCI-H1975 | PCNA | Overexpression of EPB41L4A-AS2 could promote apoptosis in NSCLC. | (86) |
| NBAT-1 | Human | A549 | RAC1 | NBAT-1 by downregulating RAC1 could promote Cell Apoptosis in NSCLC. | (87) |
| PICART1 | Human | BEAS-2B, A549, SPC-A-1, NCI-H358, NCI-H1975, HCI-H292 | Twist1, MMP2/9, E-cadherin, Cyclin D1, p21, Bcl-2, Bax, Caspase-3, STAT3, JAK2 | PICART1 via inhibiting JAK2/STAT3 signaling could promote apoptosis in NSCLC. | (30) |
| CASC2 | Human | 16HBE, A549, H1299 | p62,Atg-5, LC3-I, LC3-II, LC3-II/I, TRIM16, | CASC2 by regulating the miR-214/TRIM16 axis could promote apoptosis in NSCLC. | (88) |
| LINC00961 | Database | A549, H226 | PCNA, Bax | LINC00961 via regulating PCNA could induce cell apoptosis in NSCLC. | (89) |
| LINC02418 | 16HBE, A549, PC-9 | miR-4677-3p, SEC61G | LINC02418 via regulating miR-4677-3p/SEC61G could regulate apoptosis in NSCLC. | (90) | |
| 00312 | Human, mice | A549, SPC-A1, H1299, H1975, PC9, H1703, H520, SK-MES | HOXA5 | lncRNA00312 via inhibiting HOXA5 could promote apoptosis in NSCLC. | (91) |
| TRPM2-AS | Human | A549, H1299 | SHC1 | Knockdown of TRPM2-AS could increase cell apoptosis in NSCLC. | (92) |
| MEG3 | Human, mice | A549 | miR-205-5p, LRP1, p53,p21, Caspase-3 | MEG3 through the miR-205-5p/LRP1 pathway could regulate apoptosis in NSCLC. | (46) |
| TUG1 | Human | 16HBE, A549, SPC-A1, PC-9, H1299, H1975 | EZH2, Bax, BCL2, BCL2A1, PARP2, BIRC3, MCL1, BAK1, CASP9, CASP3 | TUG1 through the epigenetic silencing of BAX could suppress apoptosis in LUAD. | (21) |
| LINC00857 | Human | BEAS-2B, H1229, H838 | miR-1179, SPAG5 | LINC00857 via targeting the miR-1179/SPAG5 axis could regulate apoptosis in lung adenocarcinoma. | (93) |
| LINC00472 | Human | BEAS-2B, A549, H1299, H460, H446 | miR-24-3p, DEDD | LINC00472 by regulating miR-24-3p/DEDD could promote Apoptosis of LUAD, | (94) |
| AFAP1-AS1 | Murine | A549 | miR-545-3p, HDGF | Knockdown of AFAP1-AS1 by regulating the miR-545-3p/HDGF axis could promote apoptosis in lung cancer. | (95) |
| ZEB2-AS1 | Human | MRC-5, 95D, H-125, A549, NCI-H292, H1975 | Bcl-2, Bax, Caspase-3/9 | In A549 and NCI−H292 cells, knockdown of ZEB2-AS1 could inhibit cell proliferation, while in H-125 and H1975 cells overexpression of ZEB2-AS1 could inhibit cell apoptosis. | (96) |
| NORAD | Human | H460, H1299, A549, HBE, SCLC-21H | ADAM19, miR-30a-5p | Knockdown of NORAD via regulating miR-30a-5p/ADAM19 could promote cell apoptosis in LC | (97) |