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. 2021 Jul 30;16:5211–5232. doi: 10.2147/IJN.S319092

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© 2021 Gao et al.

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In vitro anti-cancer study of the mBim/DMP-039 complex. (A) The level of Bim mRNA in C26 cells after transfection (**P < 0.01). (B) The level of Bim protein in each treatment group. (C) Image of C26 cells after treatment with the mBim/DMP-039 complex (scale bar: 100 μm) (**P < 0.01, ****P < 0.0001). Cell viabilities were measured by the MTT assay. (D) Detection of the anti-proliferation effect of the mBim/DMP-039 complex by clonogenic assay. Inhibition rates were calculated based on clone numbers (***P < 0.001, ****P < 0.0001). (E) The mBim/DMP-039 complex efficiently induced apoptosis in C26 cells as determined by flow cytometry (**P < 0.01). (F) Western blot analysis of apoptosis-related proteins.