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. 2021 Jul 21;9:687868. doi: 10.3389/fcell.2021.687868

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Copyright © 2021 Lei, Cui, Yang, Piao, Inoue, Wu, Li, Kuzuya and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pitavastatin mitigated MMP-2/-9 expression/activity and targeted protein expressions in the aortic roots. (A,B) Representative gelatin zymography images and quantitative data for MMP-9 and MMP-2 activities. (C,D) Representative Western blot images and quantitative data show the protein expressions of P16^INK4a, P21, Sirt-1, and Adip R-1. (E) Exenatide elevated APN gene expression in the stressed mouse inguinal adipose tissue-derived immature adipocytes. Values are presented as means ± SEM (n = 3–6). p < 0.05, p < 0.01 vs. Stress group by Student’s t-test and one-way ANOVA followed by Tukey post hoc tests.