Figure 3. FIGURE 3: Schematic model of PDLIM1-mediated cancer progression.

PDLIM1 expression is down-regulated in CRC cells, thus reducing the binding of β-catenin/E-cadherin complex and subsequent β-catenin nuclear translocation to initiate EMT and metastatic process. In HCC cells, loss of PDLIM1 leads to the formation of excessive F-actin, further inducing LATS1 dephosphorylation, inactivating the Hippo pathway and promoting HCC metastasis. Moreover, PDLIM1 expression is regulated by miRNAs such as miR-370-3p, subsequently affecting downstream pathways.