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. 2021 Jul 23;24(3):677. doi: 10.3892/mmr.2021.12316

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Regulatory mechanisms of CLDN6 expression in other tumours. The expression ↑ is increased, ↓ decreased, + is promoting effect and -is inhibiting effect. CLDN6, claudin 6; LATS1/2, large tumor suppressor 1 and 2; EMT, epithelial mesenchymal transition; YAP1, Yes-associated protein1; PI3K, phosphatidylinositol 3-kinase; MAPK, mitogen-activated protein kinase; ERK, extracellular regulated protein kinases; AKT, protein kinase B; EGFR, epidermal growth factor receptor; mTOR, mammalian target of rapamycin; ITH, intratumoral heterogeneity; AF-6, Protein AF-6; TSG, tumour suppressor gene; PRT, promote tumour progression, INT, inhibition of tumour progression.