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. 2021 Jul 21;13:688587. doi: 10.3389/fnagi.2021.688587

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Copyright © 2021 Lin, Shen, Lu, Liang, Zhang, Xie and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of WS635, CsA, and the anesthesia/surgery on cognitive function in mice detected in Barnes maze. (A) The effects of WS635 with 13.2 mg/kg and 26.4 mg/kg on the anesthesia/surgery-induced changes in Barnes maze’s escape latency at testing day (11 days after the anesthesia/surgery) in mice. (B) The effects of WS635 with 52.8 mg/kg and CsA on the anesthesia/surgery-induced changes in Barnes maze’s escape latency at testing day (11 days after the anesthesia/surgery) in mice. N = 14–17 mice in each group. Two-way ANOVA with the post hoc Bonferroni correction was used. *P < 0.05. P values refer to the difference among different conditions on the escape latency. CsA, cyclosporine A.