Fig. 1.

Diagnostic serologic algorithm in suspected latex allergy. Modified⁵² reused with permission. ∗ Use of non-standardized NRL reagents may result in false positive test or even adverse allergic reactions. ∗ ∗Application of CCD tools [like horseradish peroxidase (HRP)] and/or inhibition studies with ‘cross-reactive carbohydrate determinants’ (CCD) to clarify protein epitopes (with clinical relevance) or the glyco-epitopes (with low clinical relevance)