FIGURE 1.

Therapeutic effects of kakonein on cardiac inter‐endothelial junction disruption in hyperglycaemic mice. (A) Molecular structural formula of puerarin. (B) Effect of kakonein on fasting blood glucose in hyperglycaemic mice (n = 8). (C) Fluorescence indicating the effect of kakonein or metformin hydrochloride on ZO‐1 (green) with VWF (red) co‐localization. (D) Quantitative analysis of the co‐localization of ZO‐1 with vWF (n = 8). (E) Fluorescence indicating the effect of kakonein or metformin hydrochloride on ZO‐2 (green) with VWF (red) co‐localization. (F) Quantitative analysis of the co‐localization of ZO‐2 with vWF (n = 8). ^## P < .01 compared with the control. **P < .01 compared with hyperglycaemia