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. 2021 Jun 27;25(15):7169–7180. doi: 10.1111/jcmm.16747

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Therapeutic effect of kakonein on the recovery of the integrity of the endothelium under high glucose by inhibiting the NLRP3 inflammasome. (A) Representative fluorescence images of ZO‐1 (n = 4). (B) ZO‐1 expression was represented by a histogram of fluorescence intensity (RFI). (C) Representative images of immunofluorescence indicating the effects of MCC950 and kakonein on ZO‐1 under high‐glucose stimulation (n = 4). (D) ZO‐1 expression was represented by a histogram of fluorescence intensity (RFI)