FIGURE 1.

CircTASP1 was up‐regulated in AML patients and cells. A, Heat map of 19 expressed circRNAs AML patients and normal healthy individuals according to circRNA microarray data set (GSE116617). B, Expression of circTASP1 was up‐regulated in 8 patients with AML compared with 4 normal individuals, which was detected by qRT‐PCR assay. C, CircTASP1 expression could not be influenced by RNase R digestion. D, CircTASP1 expression in patients with AML was higher than that in normal individuals as detected by qRT‐PCR. E, Kaplan‐Meier curve of survival of patients with AML according to circTASP1 expression (mean value as cut‐off). F, CircTASP1 was up‐regulated in AML cell lines (HL60, THP‐1, U937 and KG‐1). G, RNA‐FISH was utilized to examine the localization of circTASP1 in HL60 and THP‐1 cells. *P < .05; **P < .01. Each experiment was repeated 3 times