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. 2021 Jul 2;25(15):7342–7353. doi: 10.1111/jcmm.16763

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Aberrant Glu‐GluR2‐Parkin pathway triggered mitophagy‐mediated hippocampal neurons apoptosis in DD rats. (A)Mitophagy and autophagosome detected by transmission electron microscope in each group. The ‘blue arrow’ represents for the normal mitochondria and the ‘yellow arrow’ shows the mitophagy. (B‐F)Expression of Glu‐GluR2‐Parkin pathway protein and endogenous apoptotic protein for Cyt‐c detected by Western blot assay in each group (n = 3; **P < .001vs Con; ^# P < .05, ^## P < .01 vs DD)