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. 2021 Jul 22;24(3):675. doi: 10.3892/mmr.2021.12314

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — CAPN1 overexpression abrogates the effect of miR-140-5p on H/R-induced cell injury. The AML-12 cells were transfected with miR-140-5p mimics and/or CAPN1 overexpression plasmid in the H/R-induced cell injury model. (A) Relative cell viability, (B) LDH release, (C-E) inflammatory cytokines IL-1β, IL-6, and TNF-α, (F) cell apoptosis and (G) apoptotic rate analysis, (H) western blot analysis and (I) quantification of the protein levels of Bax, Bcl-2 and cleaved caspase-3. *P<0.05 and **P<0.01 vs. the control group; ^#P<0.05 and ^##P<0.01 vs. the H/R group; ^&P<0.05 vs. the H/R + mimics group. CAPN1, calpain 1; miR, microRNA; H/R, hypoxia/reoxygenation; NC, negative control; LDH, lactate dehydrogenase; IL, interleukin; TNF, tumor necrosis factor.