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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Jul 8;28(7):554–563. doi: 10.1038/s41594-021-00616-3

Extended Data Fig. 5. Comparison of TRPV14C,APO, TRPV14C,CAP, TRPV125C,CAP and the published structure of TRPV1 in the presence of capsaicin.

Extended Data Fig. 5

a, Close-up view of the S1-S4 domain of TRPV14C,APO (blue) and TRPV14C,CAP (cyan). Capsaicin (red) and phosphatidyl inositol (blue) molecules are shown as sticks. b, Close-up view of capsaicin in the vanilloid pocket of TRPV14C,CAP. The cryo-EM density is shown at 0.025 thresholding. c, Side view comparison of TRPV14C,CAP (cyan) and TRPV125C,CAP (green). d, Side view comparison of TRPV14C,CAP (green) and the published TRPV1 structure in the presence of capsaicin (PDB ID: 3J5R, brown).