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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Jul 8;28(7):554–563. doi: 10.1038/s41594-021-00616-3

Extended Data Fig. 6. Comparison between the overall structures of TRPV14C,APO, TRPV148C,CAP,OPEN and DkTx/RTx-bound TRPV1.

Extended Data Fig. 6

a, Comparison of TRPV14C,APO (silver), TRPV148C,CAP,OPEN (red), and DkTx/RTx-TRPV1 (blue) viewed from the intracellular side. ARD/CD movement occurs at an individual protomer level. b, Comparison of the S6b and TRP domain of TRPV14C,APO, TRPV148C,CAP,OPEN, and DkTx/RTx-TRPV1. c, Close-up view of TRPV14C,APO, TRPV148C,CAP,OPEN, and DkTx/RTx-TRPV1 in the cytoplasmic domains. d, Alternate angle and close-up view of TRPV14C,APO, TRPV148C,CAP,OPEN, and DkTx/ RTx-TRPV1 in the cytoplasmic domains.