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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Jul 8;28(7):554–563. doi: 10.1038/s41594-021-00616-3

Extended Data Fig. 7. Comparison of TRPV148C,CAP,OPEN and DkTx/RTx-bound TRPV1 structures.

Extended Data Fig. 7

a, The overlapping locations of phospholipid (TRPV148C,CAP,OPEN, red) and DkTx (DkTx/RTx-TRPV1, blue), shown as sticks and spheres, between the pore loop and pore helix. Several side chains are shown as sticks to illustrate the differences in the outer pore of the two structures. b, Structural differences between TRPV148C,CAP,OPEN and DkTx/RTx-TRPV1 at S6, the S4-S5 linker, and the TRP helix.