a-f, cryo-EM density for subdomains in TRPV14C,APO
(a, thresholding 0.014), TRPV14C,CAP
(b, thresholding 0.014), TRPV125C,CAP (c, thresholding 0.025), TRPV148C,APO
(d, thresholding 0.019), TRPV148C,CAP,INT
(e, thresholding 0.28), TRPV148C,CAP,OPEN (f, thresholding 0.3). Structural elements are shown as sticks and EM density as gray mesh.