Table 2.

Expression of hypoxia inducible factor -1α before and after melatonin and placebo administration

Tissue HIF-1α	Median (range)		P
	Melatonin (n=13)	Placebo (n=12)
Before	0.018 (0.0030-0.142)	0.0048 (0.0005-0.254)	0.301
After	0.012 (0.0014-0.139)	0.0087 (0.0004-0.060)
Change	−0.008	0.0027
After-before	−0.131 ⟶ +0.085	−0.238 ⟶ +0.053

HIF: Hypoxia-inducible factor