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Mechanism diagram. HHLA2 deficiency inhibited the proliferation, migration, invasion, and induced G0/G1 arrest of A549 and H1299 cells by inactivating EGFR/MAPK/ERK signaling pathway. In addition, knockdown of HHLA2 in A549 and H1299 cells inhibited M2 polarization of THP‐1 macrophages via decreasing the secretion of IL‐10
