FIGURE 1.

Signaling pathways involved in IL‐25/IL‐25R signaling. IL‐25 ligation to IL‐17RA/IL‐17RB complex recruits adaptor proteins such as Act1, which mediates signal transduction. Act1 employs TRAF6 protein to induce inflammation via transcription factors NF‐κB and AP‐1. TRADD is another recruited adaptor protein to IL‐25R complex, which mediates apoptosis. Also, this receptor complex mediates cancer cell stemness by inducing MAPK/PI3K pathway. Moreover, IL‐25R overlaps with EGFR signaling pathway via activating JAK2/STAT3