Table 3.

Preferred antibiotic regimen

Organism	Intravenous antibiotic	Oral antibiotic
Empiric antibiotic regimen In case of beta lactam allergies:	Amoxicillin/clavulanic acid 1200 mg QID Ceftriaxone 2 g qd + metronidazole 500 mg TID Clindamycin 600 mg TID + ciprofloxacin 400 mg TID	Amoxicillin/clavulanic acid 625 mg TID Clindamycin 600 mg TID AND Ciprofloxacin 750 mg BID
Staphylococcus aureus (MSSA) and methicillin-sensitive coagulase-negative staphylococci	Flucloxacillin 6 g/24 h	Clindamycin 600 mg TID Trimethoprim/sulfamethoxazole (co-trimoxazole) 960 mg BID
Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci	Vancomycin (follow local antibiotic guideline for dosage) Teicoplanin (follow local antibiotic guideline for dosage)	Clindamycin 600 mg TID Trimethoprim/sulfamethoxazole (Co-trimoxazole) 960 mg BID Linezolid 600 mg BID Moxifloxacin 400 qd
Beta haemolytic streptococci	Penicillin 12 mil U/24 h	Clindamycin 600 mg TID Doxycycline 200 mg BID
Enterococci	Amoxicillin 6 g/24 h Vancomycin (follow local antibiotic guideline for dosage)	Amoxicillin 1000 mg TID Linezolid 600 mg BID
Enterobacteriaceae	Amoxicillin 6 g/24 h Ceftriaxone 2 g qd Ciprofloxacin 400 mg TID	Ciprofloxacin 750 mg BID Trimethoprim/sulfamethoxazole (co-trimoxazole) 960 mg BID
Non-fermenting gram-negative rods, e.g. Pseudomonas, Enterobacter	Ceftazidime 3 g/24 h Ciprofloxacin 400 mg TID	Ciprofloxacin 750 mg BID
Anaerobes (gram-negative, e.g. Bacteroides)	Metronidazole 500 mg TID Clindamycin 600 mg TID	Metronidazole 500 mg TID Clindamycin 600 mg TID
Anaerobes (gram-positive, e.g. Cutibacterium acnes, Finegoldia)	Penicillin 12 mil U/24 h Doxycycline 200 mg BID	Amoxicillin 1000 mg TID Doxycycline 200 mg BID

The dosages and intervals are not adjusted to renal function. MSSA methicillin-sensitive S. aureus, MRSA methicillin-resistant S. aureus, BID two times per day, TID three times per day, qd daily, QID four times per day