Table 5.
List of burn-specific metabolic pathways identified in serum from the analysis of total significantly (P < .05, ppm < 2, uniquely mapped to HMDB ID) modulated metabolites
| Seq # | Time Point | Normalization Method | Pathway |
|---|---|---|---|
| 1 | h2, h6 | Sham | Mitochondrial beta-oxidation of long chain saturated fatty acids |
| h6, h24 | BL | ||
| 2 | h6 | Sham and Baseline | Mitochondrial beta-oxidation of medium chain saturated fatty acids |
| 3 | Mitochondrial beta-oxidation of short chain saturated fatty acids | ||
| 4 | Nicotinate and nicotinamide metabolism | ||
| 5 | Pantothenate and CoA biosynthesis | ||
| 6 | Riboflavin metabolism | ||
| 7 | Thiamine metabolism | ||
| 8 | Phenylacetate metabolism | ||
| 9 | Ammonia recycling | ||
| 10 | Butyrate metabolism | ||
| 11 | Cysteine metabolism | ||
| 12 | Purine metabolism | ||
| 13 | Pentose phosphate pathway | ||
| 14 | Sham | Amino sugar metabolism | |
| 15 | h24 | Baseline | Fatty acid elongation in mitochondria |
| 16 | Phosphatidylinositol phosphate metabolism | ||
| 17 | Steroid biosynthesis | ||
| 18 | Steroidogenesis |
Details noted include the time point(s) in which a specific pathway was identified, as well as the normalization method (ie, relative to sham-treated and/or baseline samples).