Table 8.
Burn-specific pathways found in skin biopsies from burn animals and not in sham-treated animals using complete lists of SMMs (P < .05, ppm < 2 and uniquely mapped to HMDB ID) at each time point after normalization to BL or to results from sham-treated biopsies at the same time point
| Number of Time-Points at Which Pathway Was Found | |||
|---|---|---|---|
| Order of Predicted Impact (Highest on Top) | Pathway Name | Normalized to Sham (3 Total) | Normalized to BL (4 Total) |
| 1 | Caffeine metabolism | 3 | 4 |
| 2 | Inositol phosphate metabolism | 3 | 4 |
| 3 | Ascorbate and aldarate metabolism | 3 | 4 |
| 4 | Pentose phosphate pathway | 3 | 4 |
| 5 | Histidine metabolism | 2 | 3 |
| 6 | Nicotinate and nicotinamide metabolism | 2 | 3 |
| 7 | Terpenoid backbone biosynthesis | 3 | 2 |
| 8 | One carbon pool by folate | 1 | 3 |
| 9 | Folate biosynthesis | 2 | 1 |
| 10 | Cysteine and methionine metabolism | 1 | 2 |
| 11 | Taurine and hypotaurine metabolism | 2 | 1 |