FIGURE 1.

Schematic illustration of the machine learning‐based multimodal analysis of the triple tumor biomarkers – CTCs, exosomes, and cfDNA: (A) A graphical abstract of the multimodal liquid biopsy analysis. (B) Schematic illustration depicting the experimental and analytical procedures for the isolation of CTCs, exosomes, and cfDNA using functionalized alginate beads. (C) Clustering of the CTC counts, exosome NA amounts, and plasma cfDNA concentrations based on the machine learning algorithm; (D) Establishment of MMLB_Score for each cohort based on PCA. (E) Validation of the clinical utility of the MMLB analysis