Fig. 2.

Spatial metabolite profiles determined by multi-voxel analyses. a Multi-voxel spectroscopy (MVS) data was acquired for patients P1, P12 and P14. The metabolite spectra acquired were simultaneously analyzed by STATIS, and the respective coordinates from the first axis were then projected as a heatmap onto the corresponding voxel on the respective MRI. The color gradient corresponds to the coordinates projected on the first axis of STATIS, as indicated. The most malignant parts of the tumors are located in the “orange-red” areas. b The first axis of STATIS shows the organization of the compromise of the 16 metabolites from MVS analyses of the three patients. The color code of the metabolites corresponds to their major function as indicated. c Comparison of the first axis of the 13 common metabolites between human MVS (spatial organization) and mouse metabolite data (temporal organization) is shown in a scatter plot, and displays a remarkable similarity (Spearman correlation = -0.68, p < 0.013). Abbreviations as in Fig. 1