Table 4.

Six months confirmed disability progression (6 months confirmed disability-progression (6mCDP)

	EDSS <3 to ≥3–<5	EDSS <5 to ≥5	Months to 6mCDP EDSS ≥3–5		Months to 6mCDP EDSS ≥5
	% Patients	% Patients	Mean	SD	Mean	SD
2010–2012	1.02	0.26	122.30	81.03	181.59	92.17
2013–2015	0.76	0.31	130.95	85.60	181.37	110.04
2016–2018	0.62	0.20	149.26	93.32	209.73	97.70
Difference from 2010–2012 to 2016–2018, %	−39	−23	+22		+15

EDSS increase of ≥1.0 for patients from previous EDSS): proportion of patients reaching EDSS≥3–5, reaching EDSS≥5 and months from first symptom of relapsing-remitting multiple sclerosis to 6mCDP in these strata.

EDSS, Expanded Disability Status Scale.