Table 2.
Modality | Target | Histology | Phase | Clinical Trial |
---|---|---|---|---|
Vaccines | ||||
Glycolipids/Glycoproteins | Theratope STn Thomsen-Friedenreich (TF) |
Breast Prostate |
3 1 |
NCT00003638 NCT00003819 |
Globo-H-GM2-sTn-TF-Tn | Ovarian | 1 | NCT01248273 | |
GD2, GD3, Globo H, Fucosyl GM1 and N-propionylated polysialic acid | Lung | 1 | NCT01349647 | |
Globo-H | Breast | 2 | NCT01516307 | |
GM2, GD2, GD3 | Sarcoma | 2 | NCT01141491 | |
GD3 | Melanoma | 2 1 |
NCT00679289, NCT03159117 |
|
GD3L, GD3L | Melanoma | 1 1 |
NCT00597272 NCT00911560 |
|
GM2 | Breast Melanoma |
3 3 |
NCT00003357 NCT00005052 |
|
Anti-idiotype | NeuGcGM3 ACA125 CEA GD2 |
NSCLC Pediatric tumors Ovarian, Colorectal Neuroblastoma |
3 1 2 2 1 |
NCT01460472 NCT01598454 NCT00058435 NCT00033748 NCT00003023 |
Peptide Carbohydrate Mimotope | LeY, GD2 | Breast Lung |
1 and 2 1/2 |
NCT02229084 NCT02264236 |
Monoclonal Antibodies | ||||
GD2 | Neuroblastoma Neuroblastoma/ Osteosarcoma |
1 1 and 2 2 2 2 3 1 and 2 |
NCT03033303 NCT01757626 NCT00089258 NCT03363373 NCT00002458 NCT01704716 NCT03860207 |
|
GD3 | Melanoma | 2 | NCT00679289 | |
LeY | Breast Ovarian |
2 2 2 |
NCT01370239 NCT01370239 NCT00617773 |
|
SLea | Pancreas Gastrointestinal cancers |
1 2 |
NCT02672917 NCT03801915 |
|
MUC1 | Ovarian, Solid tumors |
2 1 |
NCT01899599 NCT01222624 |
|
Radiolabeled mAb | GD2 | Central Nervous System, Lung, Melanoma, Neuroblastoma, Sarcoma | 2 | NCT00445965 |
Antibody drug conjugate | LeY | NSCLC Prostate Ovarian Breast |
2 2 2 2 |
NCT00051571 NCT00031187 NCT00051584 NCT00028483 |
Lectin antagonists | ||||
Selectins | Acute Myeloid Leukemia | 3 | NCT03616470 | |
Galectins | Melanoma, NSCLC, H&N, Colon cancer, Solid tumors Melanoma |
1 2 1 1 and 2 1 |
NCT02575404, NCT00110721, NCT00054977, NCT01723813, NCT02117362 |
|
Siglec-15 | H&N, NSCLC Ovarian TNBC |
1/2 | NCT03665285 | |
CAR T cells | ||||
LeY | Solid tumors Myeloid malignancies |
1 1 and 2 |
NCT03851146 NCT02958384 |
|
CEA | Pancreatic | 2 and 3 |
NCT04037241 NCT03818165 |
|
GD2 | Glioma Neuroblastoma, Osteosarcoma B cell lymphoma |
1 1 1 1 and 2 1 and 2 1 1 1 and 2 |
NCT04099797 NCT04196413 NCT04099797 NCT04637503 NCT03373097 NCT01953900 NCT02107963 NCT04429438 |
|
Bispecific Antibodies | GD2 | Neuroblastoma | 1 and 2 | NCT02173093 |
CAR, chimeric antigen receptor; CEA, carcinoembryonic antigen; H&N, head and neck cancer; mAbs, monoclonal antibodies; NB, neuroblastoma; NSCLC, non small cell lung cancer; sTn, sialyl Tn; TNBC, triple negative breast cancer.