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. 2021 Jun 23;40(3):89–100. doi: 10.1089/mab.2021.0024

Table 2.

Clinical Trials Targeting Carbohydrate Antigens

Modality Target Histology Phase Clinical Trial
Vaccines        
Glycolipids/Glycoproteins Theratope STn
Thomsen-Friedenreich (TF)
Breast
Prostate
3
1
NCT00003638
NCT00003819
  Globo-H-GM2-sTn-TF-Tn Ovarian 1 NCT01248273
  GD2, GD3, Globo H, Fucosyl GM1 and N-propionylated polysialic acid Lung 1 NCT01349647
  Globo-H Breast 2 NCT01516307
  GM2, GD2, GD3 Sarcoma 2 NCT01141491
  GD3 Melanoma 2
1
NCT00679289,
NCT03159117
  GD3L, GD3L Melanoma 1
1
NCT00597272
NCT00911560
  GM2 Breast
Melanoma
3
3
NCT00003357
NCT00005052
Anti-idiotype NeuGcGM3

ACA125
CEA
GD2
NSCLC
Pediatric tumors
Ovarian,
Colorectal
Neuroblastoma
3
1
2
2
1
NCT01460472
NCT01598454
NCT00058435
NCT00033748
NCT00003023
Peptide Carbohydrate Mimotope LeY, GD2 Breast
Lung
1 and 2
1/2
NCT02229084
NCT02264236
Monoclonal Antibodies        
  GD2 Neuroblastoma
Neuroblastoma/
Osteosarcoma
1
1 and 2
2
2
2
3
1 and 2
NCT03033303
NCT01757626
NCT00089258
NCT03363373
NCT00002458
NCT01704716
NCT03860207
  GD3 Melanoma 2 NCT00679289
  LeY Breast

Ovarian
2
2
2
NCT01370239
NCT01370239
NCT00617773
  SLea Pancreas
Gastrointestinal cancers
1
2
NCT02672917
NCT03801915
  MUC1 Ovarian,
Solid tumors
2
1
NCT01899599
NCT01222624
Radiolabeled mAb GD2 Central Nervous System, Lung, Melanoma, Neuroblastoma, Sarcoma 2 NCT00445965
Antibody drug conjugate LeY NSCLC
Prostate
Ovarian
Breast
2
2
2
2
NCT00051571
NCT00031187
NCT00051584
NCT00028483
Lectin antagonists        
  Selectins Acute Myeloid Leukemia 3 NCT03616470
  Galectins Melanoma, NSCLC, H&N, Colon cancer,
Solid tumors
Melanoma
1


2
1
1 and 2
1
NCT02575404,


NCT00110721,
NCT00054977,
NCT01723813,
NCT02117362
  Siglec-15 H&N, NSCLC
Ovarian
TNBC
1/2 NCT03665285
CAR T cells        
  LeY Solid tumors
Myeloid malignancies
1
1 and 2
NCT03851146
NCT02958384
  CEA Pancreatic 2 and 3 NCT04037241
NCT03818165
  GD2 Glioma


Neuroblastoma, Osteosarcoma


B cell lymphoma
1
1
1
1 and 2
1 and 2
1
1
1 and 2
NCT04099797
NCT04196413
NCT04099797
NCT04637503
NCT03373097
NCT01953900
NCT02107963
NCT04429438
Bispecific Antibodies GD2 Neuroblastoma 1 and 2 NCT02173093

CAR, chimeric antigen receptor; CEA, carcinoembryonic antigen; H&N, head and neck cancer; mAbs, monoclonal antibodies; NB, neuroblastoma; NSCLC, non small cell lung cancer; sTn, sialyl Tn; TNBC, triple negative breast cancer.