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LCP delivers tumor antigen MUC1 mRNA in combination with anti-CTLA-4 mAb to treat melanoma. a) Schematic illustration of LCP (MUC1 mRNA) enhancing tumor antigen presentation and anti-CTLA-4 mAb blocking an immune checkpoint to activate T cell-mediated tumor killing. b) Tumor growth inhibition experiment. c) Flow cytometry analysis of CD8+ T cells in tumors. Adapted with permission.[188] Copyright 2018, Elsevier.
