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. 2021 Aug 4;20:76. doi: 10.1186/s12938-021-00916-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cell viability by MTT assay as a criterion for drug dose determination. In all groups, the viability rate of the cells on the 7th day was higher than that of their counterparts on the 3rd and 5th days. Also, the cell viability of both 25 and 50 μM of TQ-treated cultures was the same as the matched controls. In all days, the cell viability in 2D condition was higher than all the 3D conditions. *Significantly different from the controls on day 3 (P < 0.01), ^#significantly different from the controls on day 5 (P < 0.001), ^αsignificantly different from the controls on day 7 (P < 0.001)