Table 7.
Combined effect of chest X-ray exposure and genetic variants
| Chest X-ray exposure & number of DNA repair rare variants | Number of | Multiple imputation | ||||
|---|---|---|---|---|---|---|
| Cases | Ctrls | ORa | 95%CI | ORa | 95%CI | |
| Group ‘Low’b | ||||||
| Ever & 0 variant | 604 | 580 | 1 | 1 | ||
| Ever & 1 variant | 197 | 288 | 0.67 | 0.52-0.86 | 0.67 | 0.52-0.87 |
| Ever & 2 variants | 34 | 69 | 0.52 | 0.32-0.84 | 0.49 | 0.30-0.79 |
| Ever & ≥3 variants | 3 | 14 | 0.25 | 0.06-1.00 | 0.25 | 0.06-0.99 |
| Never | 135 | 195 | 0.50 | 0.37-0.68 | 0.31 | 0.18-0.52 |
| Continuouse | 0.69 | 0.57-0.84 | 0.69 | 0.58-0.83 | ||
| Never & 0 variant | 101 | 128 | 1 | 1 | ||
| Never & 1 variant | 27 | 50 | 0.56 | 0.30-1.06 | 0.56 | 0.30-1.05 |
| Never & 2 variants | 7 | 16 | 0.52 | 0.17-1.57 | 0.48 | 0.16-1.44 |
| Never & ≥3 variants | 0 | 1 | - | - | ||
| Ever & 0 variant | 604 | 580 | 1.67 | 1.19-2.34 | 1.66 | 1.18-2.34 |
| Ever & 1 variant | 197 | 288 | 1.12 | 0.77-1.62 | 1.12 | 0.77-1.64 |
| Ever & 2 variants | 34 | 69 | 0.86 | 0.50-1.51 | 0.82 | 0.46-1.43 |
| Ever &≥3 variants | 3 | 14 | 0.42 | 0.10-1.71 | 0.42 | 0.10-1.71 |
| Group ‘No Effect’c | ||||||
| Ever & 0 variant | 484 | 535 | 1 | 1 | ||
| Ever & 1 variant | 258 | 318 | 0.96 | 0.76-1.22 | 0.97 | 0.76-1.23 |
| Ever & 2 variants | 81 | 78 | 1.12 | 0.76-1.65 | 1.15 | 0.77-1.70 |
| Ever & ≥3 variants | 15 | 20 | 1.21 | 0.55-2.70 | 1.28 | 0.57-2.87 |
| Never | 135 | 195 | 0.58 | 0.43-0.78 | 0.61 | 0.40-0.94 |
| Continuouse | 1.02 | 0.86-1.21 | 1.05 | 0.90-1.21 | ||
| Never & 0 variant | 74 | 114 | 1 | 1 | ||
| Never & 1 variant | 45 | 67 | 1.08 | 0.62-1.90 | 1.08 | 0.61-1.89 |
| Never & 2 variants | 14 | 12 | 1.40 | 0.55-3.59 | 1.50 | 0.59-3.84 |
| Never & ≥3 variants | 2 | 2 | 1.90 | 0.23-15.8 | 1.93 | 0.23-16.1 |
| Ever & 0 variant | 484 | 535 | 1.85 | 1.27-2.70 | 1.85 | 1.27-2.71 |
| Ever & 1 variant | 258 | 318 | 1.77 | 1.19-2.65 | 1.78 | 1.19-2.66 |
| Ever & 2 variants | 81 | 78 | 2.07 | 1.25-3.42 | 2.13 | 1.29-3.54 |
| Ever & ≥3 variants | 15 | 20 | 2.24 | 0.95-5.32 | 2.39 | 1.01-5.64 |
| Group ‘High’d | ||||||
| Ever & 0 variant | 343 | 551 | 1 | 1 | ||
| Ever & 1 variant | 327 | 291 | 2.06 | 1.62-2.63 | 2.07 | 1.62-2.65 |
| Ever & 2 variants | 122 | 93 | 2.34 | 1.66-3.31 | 2.28 | 1.60-3.23 |
| Ever & ≥3 variants | 46 | 16 | 4.61 | 2.34-9.08 | 4.65 | 2.35-9.22 |
| Never | 135 | 195 | 0.85 | 0.63-1.16 | 0.74 | 0.49-1.13 |
| Continuouse | 1.67 | 1.42-1.96 | 1.66 | 1.44-1.90 | ||
| Never & 0 variant | 70 | 104 | 1 | 1 | ||
| Never & 1 variant | 46 | 62 | 0.90 | 0.51-1.58 | 0.88 | 0.50-1.54 |
| Never & 2 variants | 13 | 23 | 0.66 | 0.27-1.57 | 0.58 | 0.24-1.41 |
| Never & ≥3 variants | 6 | 6 | 2.01 | 0.54-7.48 | 2.01 | 0.54-7.45 |
| Ever & 0 variant | 343 | 551 | 1.12 | 0.75-1.65 | 1.10 | 0.75-1.63 |
| Ever & 1 variant | 327 | 291 | 2.30 | 1.54-3.44 | 2.28 | 1.53-3.40 |
| Ever & 2 variants | 122 | 93 | 2.61 | 1.63-4.19 | 2.51 | 1.56-4.03 |
| Ever & ≥3 variants | 46 | 16 | 5.15 | 2.43-10.9 | 5.10 | 2.41-10.8 |
Abbreviations: OR (95%CI) odds ratio (95% confidence interval)
aAdjusted for age at censoring, birth cohort (≤1945; 1946-1959; ≥1960), number of full-term pregnancies (>2; 1-2; 0), mammography use (never; ever), educational level (intermediate/high; basic; not graduated), BMI (18.5-24.99; <18.5; ≥25 and <30; ≥30), smoking (no; current; past), and two other DNA repair genes groups
bat least one variant in a gene from Group ‘Low’
cat least one variant in a gene from Group ‘No Effect’
dat least one variant in a gene from Group ‘High’
e“Never” excluded