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. 2021 Aug 3;23:82. doi: 10.1186/s13058-021-01461-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Characterization of the FGFR2-SKI fusion identified in the KCC_P_4043 PDX model. a Integrative Genomic Viewer results for breakpoint regions of chromosome 10 (containing FGFR2) and chromosome 1 (SKI). b Junction break point sequence of FGFR2-SKI fusion. Pink, FGFR2 exon 17; blue, SKI exon 2. c Analysis of FGFR2 in the KCC_P_4043 using SNP arrays. Top three tracks are copy number raw logRatio data from the array; middle three tracks are copy number segmentation from the raw logRatio; bottom three tracks are smoothed copy number signal. The red box highlights FGFR2 on chromosome 10. d Schematic of the FGFR2-SKI fusion in KCC_P_4043. Domain structure and amino acid residues of FGFR2 and SKI are indicated. In FGFR2, IgI–IgIII: immunoglobulin 1–3. TM: transmembrane domain. In SKI, R-smad: corresponding binding domain. DHD: Dachshund homology domain. SAND: Sp100, AIRE1, NucP41/75 and DEAF1. NLS: nuclear localization sequence. The dotted line highlights the junction between FGFR2 and SKI. e Confirmation of FGFR2-SKI expression by Western blotting. Protein lysates from 9 PDX samples were immunoblotted with a FGFR2 N-term antibody. MFM-223 and MDA-MB-468 lysates were used as positive and negative controls, respectively