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. 2021 Jun 3;8(15):2100233. doi: 10.1002/advs.202100233

Figure 2.

Figure 2

HBO depletes ECM in aberrant mechanical TME. A) GO enrichment analysis of the differentially expressed genes between HBO group and control group. B) Representative immunofluorescence staining of HIF‐1α images, MASSON staining images, second harmonic generation (SHG) images, and immunofluorescence staining of fibronectin images of tumor tissue. Quantification of HIF‐1α C), collagen in MASSON staining D), and SHG E), fibronectin in immunofluorescence staining F) of tumor tissue sections, respectively. G) Normalized solid stress of 4T1 orthotopic tumors after various treatments. Error bars indicate SEM (n = 20). Statistical significance was calculated by t‐test. P‐values: *, P < 0.05; **, P < 0.01; ***, P < 0.001.