Table 1.
Characteristics of the study population
| Variable | Participant type | Total (n = 155) | |
|---|---|---|---|
| TB‐index cases (n = 124) | TB contacts (n = 31) | ||
| Age, years | 36.0 (30.6 to 44.5) | 34.0 (27.0 to 39.7) | 35.9 (29.9 to 43.8) |
| Male sex | 72 (58) | 11 (35) | 83 (54) |
| Inpatient at recruitment | 65 (52) | 0 | 65 (42) |
| Body mass index a , kg/m2 | 19.4 (17.5 to 21.5) | 23.4 (20.8 to 25.6) | 19.9 (17.9 to 23.0) |
| Haemoglobin < 8 g/dL | 29 (23) | 1 (3) | 30 (19) |
| Abnormal ALT (≥1.5 ULN) | 10 (8) | 0 | 10 (6) |
| eGFR<60 mL/min/1.73 m2 | 20 (16) | 0 | 20 (13) |
| CD4 cells/μL | 105.0 (38.5 to 258.5) | 355.0 (255.0 to 605.0) | 132.0 (47.0 to 337.0) |
| Danger signs | 75 (60) | 2 (6) | 77 (50) |
| ART status | |||
| New case | 28 (23) | 16 (52) | 44 (28) |
| ART naïve | 36 (29) | 5 (16) | 41 (26) |
| Suboptimal adherence | 44 (35) | 1 (3) | 45 (29) |
| Interrupter | 16 (13) | 9 (29) | 25 (16) |
| WHO stage | |||
| Stage 1 or 2 | 0 | 26 (84) | 26 (17) |
| Stage 3 or 4 | 124 (100) | 5 (16) | 129 (83) |
| CD4 < 100 cells/μL | 60 (48%) | 1 (3%) | 61 (39%) |
| CD4 < 200 cells/μL b | 87 (70) | 5 (16) | 92 (59) |
| Advanced HIV disease c | 124 (100) | 9 (29) | 133 (86) |
Data are shown as median (IQR) or n (%). ALT, alanine aminotransferase; eGFR, estimated creatinine glomerular filtration rate GFR (CKD‐EPI formula); ART, antiretroviral therapy; Danger signs, any of the following present: Heart rate >120 beats per minute, respiratory rate >30 breaths per minute, Systolic blood pressure <90 mmHg, body temperature >39° Celsius, moderate or severe dehydration, bedridden or needing aid to walk, altered mental state, other neurological problem.
a
n=153 (two missing values)
b
includes also those with <100 cells/μL
c
AHD defined as having CD4 < 200 cells/μL or WHO stage 3 or 4.