Figure 10.

dpysl2 and stmn1/2 MO-injected zebrafish larvae showed reduced optokinetic reflex. A, Effect of the dpysl2 MO injection on the abduction and adduction range of movements separated into dominant and weak eyes. In all cases, injected fish showed higher variability and values in the lowest range. B, Similar results observed in the case of saccadic velocity. C, D, Gain curves for abduction (C) and adduction (D) movements. dpysl2 MO-injected fish show lower gain levels, for both dominant and weak eyes, and especially affecting adduction. Noninjected, n = 16; dpysl2 MO, n = 14. Values were compared using two-factor ANOVA with replication: **p < 0.01. E, Effect of the stmn1a + stmn1b + stmn2a + stmn2b MO injection on the abduction and adduction range separated into dominant and weak eyes. F, Saccadic velocity. G, H, Gain curves for abduction (G) and adduction (H) movements. Standard MO, n = 41; stmn1/2 MO, n = 39. Range and saccadic velocity were compared using the t test; gain compared using two-factor ANOVA analysis with replication: *p < 0.05, **p < 0.005, ***p < 0.0005. ns, Nonsignificant.