Figure 11.

α2-CHN is an integrator of multiple signaling pathways. Proposed model of the role of α2-CHN as an integrator of extracellular signals. α2-CHN serves as a link between extracellular signaling cues acting in the OMS (based on the published literature) and the modulation of cytoskeletal dynamics. We propose that α2-CHN acts as a scaffold for the microtubule-interacting proteins CRMP2 and STMN1/2, and potentially for the engagement of their kinases, allowing for changes in phosphorylation (i.e., its function). This in turn would cause changes in microtubule stability and affect axonal growth.