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. 2021 Aug 4;16(8):e0249647. doi: 10.1371/journal.pone.0249647

Table 2. Summary of imaging findings and analysis of their difference in relation to tumor type using Fisher’s exact test.

Imaging findings DMG n (%) mGBM-H3wt n (%) p-value
Location thalamus 9/24 (37.5) 0.129 0.095
brainstem 12/24 (50) 0.351 0.224
spinal cord 3/24 (12.5) 0.618 0.417
Edema present 6/24 (25) 15/19 (79) 0.001
Rim enhancement 10/24 (42) 13/19 (68) 0.125
Tumor necrosis 17/24 (71) 17/19 (89) 0.257
Strong enhancement 3/24 (12.5) 11/19 (58) 0.003
Low enhancement 12/24 (50) 3/19 (16) 0.026
Mass effect 24/24 (100) 19/19 (100)
Multifocal lesions 0 3/19 (16)

DMG: Diffuse midline glioma, H3 K27M-mutant; mGBM-H3wt: Glioblastoma of the midline structures without H3F3A/HIST1H3B mutations.