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. 2021 Jul 23;19(7):e3001344. doi: 10.1371/journal.pbio.3001344

Fig 4. Comparison of C9orf72-SMCR8N-C complex with FLCN-FNIP2 complex.

Fig 4

(A) Superposition of full-length (left top) and the individual uDenn (left bottom), cDenn (right top) and dDenn (right bottom) domains of C9orf72 (yellow orange) protein on the full-length and the individual uDenn, cDenn, and dDenn domains of FNIP2 (cyan) protein (PDB: 6ULG) [28]. (B) Superposition of full-length (left top) and the individual uDenn (left bottom), cDenn (right top), and dDenn (right bottom) domains of SMCR8N-C (salmon pink) protein on the full-length and the individual uDenn, cDenn, and dDenn domains of FLCN (green) protein (PDB: 6ULG) [28]. (C) Structural-based sequence alignment of a region in the uDenn domains of SMCR8 and FLCN. The residue numbers are indicated. The blue triangle indicates the conserved arginine that is suggested to be crucial for GAP activity. cDenn, central Denn; dDenn, downstream Denn; Denn, differently expressed in normal and neoplastic cells; FLCN, folliculin; FNIP2, Folliculin Interacting Protein 2; GAP, GTPase activating protein; PDB, Protein Data Bank; uDenn, upstream Denn.