Figure 1.
Analytical pipeline for the study
Regions with significant pairwise local genetic correlation were first identified by ρHESS. For regions harboring disproportionally high shared heritability across cancers, joint test of ASSET two-sided meta-analysis and COJO conditional analysis was then repeatedly conducted to identify independent signals, until no variant reached genome-wide significance (p < 5 × 10−8) in two-sided ASSET meta-analysis. For each signal, GWAS summary statistics conditional on other signals of selected cancer were used in multi-trait fine-mapping to estimate the posterior probability of being causal.