Table 2.

Genomic regions with statistically significant local genetic correlations between cancers

Cancer site 1	Cancer site 2	Region	Region start	Region end	No. of SNPs	Direction	p valuea
ER-negative breast	prostate	1q32	203334734	204681068	2,364	negative	3.45E−06
Colorectal	prostate	4q24	105305294	107501305	2,986	positive	1.05E−05
Glioma	prostate	5p15.33	982252	2132442	2,631	negative	4.03E−19
Colorectal	glioma	5p15.33	982252	2132442	2,465	negative	1.24E−05
ER-negative breast	prostate	5p15.33	982252	2132442	3,111	negative	1.90E−05
ER-negative breast	glioma	5p15.33	982252	2132442	2,631	positive	2.40E−05
Melanoma	pancreatic	5p15.33	982252	2132442	2,849	positive	4.85E−06
Lung	pancreatic	5p15.33	982252	2132442	2,935	negative	1.39E−07
Overall breast	colorectal	5q11.2	55417349	56621102	2,131	positive	1.97E−05
Colorectal	prostate	8q24	126410917	128659111	4,275	positive	1.97E−16
ER-positive breast	prostate	10q26.13	123231465	123900545	1,481	negative	1.22E−06
Endometrial	prostate	17q12	34469036	36809344	2,748	positive	5.01E−09
ER-negative breast	ovarian	19p13.11	16374416	18409862	4,103	positive	1.11E−07

Local genetic correlation between cancers across the genome (N = 1,703 regions) was estimated using HESS.

^aCutoff of the statistical significance was defined as p < 0.05/1,703 = 2.94E−05, after adjusting for multiple comparison.