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Nucleotide metabolism is energetically expensive. De novo biosynthesis of purines (red) and pyrimidines (blue) begins with the pentose phosphate pathway (green), which generates phosphoribosyl pyrophosphate (prpp) from glycolysis (black). The energetic demand for ATP molecules to power purine and pyrimidine biosynthesis drives activity through the tricarboxylic acid (TCA) cycle (black) and oxidative phosphorylation (purple).
