REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Purified anti-human ADAM10 Antibody	BioLegend	Cat# 352702; RRID: AB_10897813
Chemicals, peptides, and recombinant proteins
Sequencing Grade Modified Trypsin	Promega	V5073
TCEP HCl (tris(2-carboxyethyl)phosphine hydrochloride)	Sigma	646547
Methanol (Optima™ LC/MS)	Fisher Scientific	Cat# A454SK-4
Water (Optima™ LC/MS)	Fisher Scientific	Cat# W6-4
Acetonitrile (Optima™ LC/MS)	Fisher Scientific	Cat# A9554
Honeywell Fluka™ Formic acid, for mass spectrometry	Fisher Scientific	Cat# 60-006-17
Phosphate Buffered Saline (PBS)	BioRad	Cat# 1610780
ProteaseMAX™ Surfactant	Promega	Cat# V2072
Dithiothreitol (DTT)	Millipore Sigma	Cat# 10708984001
Iodoacetamide (IAA)	Millipore Sigma	Cat# I1149
Triflouroacetic Acid (TFA)	Millipore Sigma	Cat# 302031
ZWITTERGENT® 3-16 Detergent	Millipore Sigma	Cat# 693023
Isopropanol (Optima™ LC/MS)	Fisher Scientific	Cat# A461-1
Deposited data
Mass Spectrometry Raw and Analyzed Data	This Study	PRIDE: PXD026483
Experimental models: Cell lines
Human Skeletal Muscle Myoblasts (HSMM)	Lonza	Cat# CC-2580
Isolated Human Platelets	Mayo Clinic Blood Bank	NA
Isolated Human Leukocytes	Donor	NA
Software and algorithms
MaxQuant Quantitative Software (v1.6.7.0)	Cox and Mann, 2008	https://www.maxquant.org/
Perseus (v1.6.7.0)	Tyanova et al., 2016	https://maxquant.net/perseus/
FlowJo (v10.5)	FlowJo	https://www.flowjo.com/
Other
qEV 2.0 Size Exclusion Chormatography Column (70nm Pore Size)	Izon	Cat# qEV 2.0
Self-Pack PicoFrit Columns 360x75x10	New Objective	Part# PF-360-75-10-N-5
EXP®2 Stem Trap	Optimize Technologies	Part# 04003HNC18
Skeletal Muscle Cell Growth Medium	Cell Applications	Cat# 151K-500
Gibco™ Dulbecco's Modified Eagle Medium/F-12 (DMEM/F-12)	Fisher Scientific	Cat# 11320
Gibco™ Fetal Bovine Serum, exosome-depleted	Fisher Scientific	Cat# A2720801
Preadipocyte Growth Medium-2 (PGM-2 Bullekit)	Lonza	cat# PT-8002
Gibco™ Fetal Bovine Serum (FBS)	Fisher Scientific	Cat# A31605