Table 1. Demographic Data and Baseline Characteristics.
| Demographic data and baseline characteristics | Switzerland, N (%) | Other countries, N (%) | Total, N (%) | P-value |
|---|---|---|---|---|
| Number of patients | 94 (100.00) | 7,514 (100.00) | 7,608 (100.00) | |
| Age at registration (years) | < 0.0001 | |||
| N | 94 | 7,514 | 7,608 | |
| Mean | 69.91 | 65.30 | 65.36 | |
| SD | 10.07 | 9.33 | 9.35 | |
| Min | 44.00 | 40.00 | 40.00 | |
| Median | 71.00 | 66.00 | 66.00 | |
| Max | 92.00 | 95.00 | 95.00 | |
| Nmiss | 0 | 0 | 0 | |
| Age at registration (categorical) | < 0.0001 | |||
| < 65 years | 23 (24.47) | 3,426 (45.59) | 3,449 (45.33) | |
| ≥ 65 years | 71 (75.53) | 4,088 (54.41) | 4,159 (54.67) | |
| Gender | 0.03 | |||
| Male | 54 (57.45) | 5,121 (68.15) | 5,175 (68.02) | |
| Female | 40 (42.55) | 2,393 (31.85) | 2,433 (31.98) | |
| Duration between initial diagnosis of COPD and baseline visit (years) | 0.03 | |||
| N | 94 | 7,514 | 7,608 | |
| Mean | 5.63 | 4.91 | 4.92 | |
| SD | 5.41 | 5.87 | 5.86 | |
| Min | 0.00 | 0.00 | 0.00 | |
| Median | 4.00 | 3.00 | 3.00 | |
| Max | 26.00 | 72.00 | 72.00 | |
| Nmiss | 0 | 0 | 0 | |
| COPD degree of severity (spirometric) | 0.00 | |||
| 1 | 5 (5.32) | 152 (2.02) | 157 (2.06) | |
| 2 | 57 (60.64) | 3,420 (45.52) | 3,477 (45.70) | |
| 3 | 29 (30.85) | 3,100 (41.26) | 3,129 (41.13) | |
| 4 | 2 (2.13) | 752 (10.01) | 754 (9.91) | |
| No previous findings | 1 (1.06) | 90 (1.20) | 91 (1.20) | |
| mMRC questionnaire | 0.41 | |||
| Grade 0 | 5 (5.32) | 246 (3.27) | 251 (3.30) | |
| Grade 1 | 23 (24.47) | 1,762 (23.45) | 1,785 (23.46) | |
| Grade 2 | 43 (45.74) | 3,167 (42.15) | 3,210 (42.19) | |
| Grade 3 | 21 (22.34) | 1,903 (25.33) | 1,924 (25.29) | |
| Grade 4 | 2 (2.13) | 436 (5.80) | 438 (5.76) | |
| GOLD Group | 0.91 | |||
| A | 20 (21.28) | 1,479 (19.68) | 1,499 (19.70) | |
| B | 39 (41.49) | 3,214 (42.77) | 3,253 (42.76) | |
| C | 8 (8.51) | 529 (7.04) | 537 (7.06) | |
| D | 27 (28.72) | 2,292 (30.50) | 2,319 (30.48) | |
| Patients with concomitant diseases | < 0.0001 | |||
| No | 4 (4.26) | 2,126 (28.29) | 2,130 (28.00) | |
| Yes | 90 (95.74) | 5,388 (71.71) | 5,478 (72.00) | |
| Patients with concomitant medication (except respiratory therapeutics) | < 0.0001 | |||
| No | 16 (17.02) | 3,008 (40.03) | 3,024 (39.75) | |
| Yes | 78 (82.98) | 4,506 (59.97) | 4,584 (60.25) | |
| Smoking status | 0.60 | |||
| Smoker | 37 (39.36) | 3,025 (40.26) | 3,062 (40.25) | |
| Ex-smoker | 47 (50.00) | 3,454 (45.97) | 3,501 (46.02) | |
| Non-smoker | 10 (10.64) | 1,035 (13.77) | 1,045 (13.74) | |
| Pack-years | 0.01 | |||
| N | 84 | 6479 | 6563 | |
| Mean | 37.93 | 35.37 | 35.41 | |
| SD | 14.19 | 20.03 | 19.97 | |
| Min | 5.00 | 0.00 | 0.00 | |
| Median | 40.00 | 32.00 | 32.00 | |
| Max | 70.00 | 292.00 | 292.00 | |
| Nmiss | 10 | 1,035 | 1,045 | |
| Patients with exacerbations in the last 12 months prior to study | 0.83 | |||
| Yes | 60 (63.83) | 4,874 (64.87) | 4,934 (64.85) | |
| No | 34 (36.17) | 2,640 (35.13) | 2,674 (35.15) | |
| Number of exacerbations in the last 12 months prior to study | 0.55 | |||
| N | 94 | 7,514 | 7,608 | |
| Mean | 1.17 | 1.08 | 1.08 | |
| SD | 1.18 | 1.10 | 1.10 | |
| Min | 0.00 | 0.00 | 0.00 | |
| Median | 1.00 | 1.00 | 1.00 | |
| Max | 5.00 | 12.00 | 12.00 | |
| Nmiss | 0 | 0 | 0 |
COPD: chronic obstructive pulmonary disease; SD: standard deviation; mMRC: modified Medical Research Council questionnaire; Nmiss: number missings.