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. 2021 Jul 28;13(7):392–402. doi: 10.14740/jocmr4542

Table 2. Analysis of Responder and Non-Responder.

Demographic data and baseline characteristics Responder
Non-responder
Responder vs. non-responder in Switzerland, P-value Responder vs. non-responder in other countries, P-value
Switzerland, N (%) Other countries, N (%) P-value Switzerland, N (%) Other countries, N (%) P-value
Number of patients 59 (100.00) 5,031 (100.00) 35 (100.00) 2,483 (100.00)
Age at registration (categorical) 0.00 0.01 0.78 0.81
  < 65 years 15 (25.42) 2,290 (45.52) 8 (22.86) 1,136 (45.75)
  ≥ 65 years 44 (74.58) 2,741 (54.48) 27 (77.14) 1,347 (54.25)
COPD degree of severity (spirometric) 0.02 0.03* 0.46* < 0.0001
  1 2 (3.39) 91 (1.81) 3 (8.57) 61 (2.46)
  2 36 (61.02) 2,156 (42.85) 21 (60.00) 1,264 (50.91)
  3 20 (33.90) 2,179 (43.31) 9 (25.71) 921 (37.09)
  4 1 (1.69) 533 (10.59) 1 (2.86) 219 (8.82)
  No previous findings 0 (0.00) 72 (1.43) 1 (2.86) 18 (0.72)
mMRC questionnaire 0.34 0.99 0.19* < 0.0001
  Grade 0 2 (3.39) 73 (1.45) 3 (8.57) 173 (6.97)
  Grade 1 11 (18.64) 931 (18.51) 12 (34.29) 831 (33.47)
  Grade 2 29 (49.15) 2,177 (43.27) 14 (40.00) 990 (39.87)
  Grade 3 16 (27.12) 1,495 (29.72) 5 (14.29) 408 (16.43)
  Grade 4 1 (1.69) 355 (7.06) 1 (2.86) 81 (3.26)
GOLD Group 0.89 0.64 0.05 < 0.0001
  A 10 (16.95) 708 (14.07) 10 (28.57) 771 (31.05)
  B 24 (40.68) 2,238 (44.48) 15 (42.86) 976 (39.31)
  C 3 (5.08) 296 (5.88) 5 (14.29) 233 (9.38)
  D 22 (37.29) 1,789 (35.56) 5 (14.29) 503 (20.26)
Patients with concomitant diseases < 0.0001 0.00 0.63* 0.37
  No 2 (3.39) 1,407 (27.97) 2 (5.71) 719 (28.96)
  Yes 57 (96.61) 3,624 (72.03) 33 (94.29) 1,764 (71.04)
Smoking status 0.62 0.89 0.81 < 0.0001
  Smoker 22 (37.29) 2,012 (39.99) 15 (42.86) 1,013 (40.80)
  Ex-smoker 30 (50.85) 2,259 (44.90) 17 (48.57) 1,195 (48.13)
  Non-smoker 7 (11.86) 760 (15.11) 3 (8.57) 275 (11.08)
Patients with exacerbations in the last 12 months prior to study 0.30 0.30 0.46 < 0.0001
  Yes 36 (61.02) 3,388 (67.34) . 24 (68.57) 1,486 (59.85)
  No 23 (38.98) 1,643 (32.66) . 11 (31.43) 997 (40.15)

*Chi-Square might not be valid, test changed to Fishers exact test. COPD: chronic obstructive pulmonary disease; mMRC: modified Medical Research Council questionnaire.