Table 2. Analysis of Responder and Non-Responder.
Demographic data and baseline characteristics | Responder |
Non-responder |
Responder vs. non-responder in Switzerland, P-value | Responder vs. non-responder in other countries, P-value | ||||
---|---|---|---|---|---|---|---|---|
Switzerland, N (%) | Other countries, N (%) | P-value | Switzerland, N (%) | Other countries, N (%) | P-value | |||
Number of patients | 59 (100.00) | 5,031 (100.00) | 35 (100.00) | 2,483 (100.00) | ||||
Age at registration (categorical) | 0.00 | 0.01 | 0.78 | 0.81 | ||||
< 65 years | 15 (25.42) | 2,290 (45.52) | 8 (22.86) | 1,136 (45.75) | ||||
≥ 65 years | 44 (74.58) | 2,741 (54.48) | 27 (77.14) | 1,347 (54.25) | ||||
COPD degree of severity (spirometric) | 0.02 | 0.03* | 0.46* | < 0.0001 | ||||
1 | 2 (3.39) | 91 (1.81) | 3 (8.57) | 61 (2.46) | ||||
2 | 36 (61.02) | 2,156 (42.85) | 21 (60.00) | 1,264 (50.91) | ||||
3 | 20 (33.90) | 2,179 (43.31) | 9 (25.71) | 921 (37.09) | ||||
4 | 1 (1.69) | 533 (10.59) | 1 (2.86) | 219 (8.82) | ||||
No previous findings | 0 (0.00) | 72 (1.43) | 1 (2.86) | 18 (0.72) | ||||
mMRC questionnaire | 0.34 | 0.99 | 0.19* | < 0.0001 | ||||
Grade 0 | 2 (3.39) | 73 (1.45) | 3 (8.57) | 173 (6.97) | ||||
Grade 1 | 11 (18.64) | 931 (18.51) | 12 (34.29) | 831 (33.47) | ||||
Grade 2 | 29 (49.15) | 2,177 (43.27) | 14 (40.00) | 990 (39.87) | ||||
Grade 3 | 16 (27.12) | 1,495 (29.72) | 5 (14.29) | 408 (16.43) | ||||
Grade 4 | 1 (1.69) | 355 (7.06) | 1 (2.86) | 81 (3.26) | ||||
GOLD Group | 0.89 | 0.64 | 0.05 | < 0.0001 | ||||
A | 10 (16.95) | 708 (14.07) | 10 (28.57) | 771 (31.05) | ||||
B | 24 (40.68) | 2,238 (44.48) | 15 (42.86) | 976 (39.31) | ||||
C | 3 (5.08) | 296 (5.88) | 5 (14.29) | 233 (9.38) | ||||
D | 22 (37.29) | 1,789 (35.56) | 5 (14.29) | 503 (20.26) | ||||
Patients with concomitant diseases | < 0.0001 | 0.00 | 0.63* | 0.37 | ||||
No | 2 (3.39) | 1,407 (27.97) | 2 (5.71) | 719 (28.96) | ||||
Yes | 57 (96.61) | 3,624 (72.03) | 33 (94.29) | 1,764 (71.04) | ||||
Smoking status | 0.62 | 0.89 | 0.81 | < 0.0001 | ||||
Smoker | 22 (37.29) | 2,012 (39.99) | 15 (42.86) | 1,013 (40.80) | ||||
Ex-smoker | 30 (50.85) | 2,259 (44.90) | 17 (48.57) | 1,195 (48.13) | ||||
Non-smoker | 7 (11.86) | 760 (15.11) | 3 (8.57) | 275 (11.08) | ||||
Patients with exacerbations in the last 12 months prior to study | 0.30 | 0.30 | 0.46 | < 0.0001 | ||||
Yes | 36 (61.02) | 3,388 (67.34) | . | 24 (68.57) | 1,486 (59.85) | |||
No | 23 (38.98) | 1,643 (32.66) | . | 11 (31.43) | 997 (40.15) |
*Chi-Square might not be valid, test changed to Fishers exact test. COPD: chronic obstructive pulmonary disease; mMRC: modified Medical Research Council questionnaire.