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. 2021 Aug 4;7(32):eabg7181. doi: 10.1126/sciadv.abg7181

Fig. 1. BCG vaccination results in diminished plasma levels of pro- and anti-inflammatory cytokines.

Fig. 1

(A) The plasma levels of type 1 cytokines, IL-1 family, and type 1 IFNs in BCG prevaccinated (M0) (n = 82) and M1 after vaccination (n = 82) and plasma levels of type 1 cytokines, IL-1 family, and type 1 IFNs in BCG-unvaccinated (UVC) (n = 55) and postvaccinated (M1) (n = 82) individuals are shown. (B) The plasma levels of proinflammatory cytokines in BCG prevaccinated (M0) (n = 82) and M1 after vaccination (n = 82) and plasma levels of proinflammatory cytokines in BCG-unvaccinated (UVC) (n = 55) and postvaccinated (M1) (n = 82) individuals are shown. (C) The plasma levels of anti-inflammatory cytokines in BCG prevaccinated (M0) (n = 82) and M1 after vaccination (n = 82) and plasma levels of anti-inflammatory cytokines in BCG-unvaccinated (UVC) (n = 55) and postvaccinated (M1) (n = 82) individuals are shown. The data are represented as scatter plots with each circle representing a single individual. For the analysis of M0 and M1, P values were calculated using the Wilcoxon matched-pair tests with Holm’s correction for multiple comparisons; for the analysis between UVC and M1, P values were calculated using the Mann-Whitney test with Holm’s correction for multiple comparisons.