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. 2021 Jul 21;11:648023. doi: 10.3389/fonc.2021.648023

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Copyright © 2021 Kim, Choi, Koh, Kim, Phi, Lee and Kim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC1 expression in AT/RT samples compared to MBL samples. (A) The quantitative polymerase chain reaction (qPCR) showed that HDAC1 mRNA expression in AT/RT tissues was 2.19 (p = 0.027) folds higher than in MB tissues. (B) HDAC1 mRNA level was tested in 3 AT/RT primary cultured cells(SNU.AT/RT-5, SNU.AT/RT-9, SNU.AT/RT-10) and each established AT/RT (BT12, BT16) and MB (UW426, MED8A) cell lines. HDAC1 is significantly overexpressed in AT/RT samples compared to the lowest expression level in UW426, one of MB cell lines. (C) IHC results show significantly higher HDAC1 protein expression in AT/RT compared to medulloblastoma. (D) The graph shows the percentage of HDAC1 positive cells in IHC (p < 0.0001). *p < 0.05, ***p < 0.0001.