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. 2021 Jul 21;11:648023. doi: 10.3389/fonc.2021.648023

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Copyright © 2021 Kim, Choi, Koh, Kim, Phi, Lee and Kim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative evaluation of the combination effect of CI-994 with conventional anticancer drugs. Curve shift analysis of CI-994 with conventional drugs (etoposide, cisplatin and 4-HC) in AT/RT cells shows that the degree of left shift represented the amount of synergism associated with the indicated drug combination. Single treatment: Black lines, Combination treatment: Pink lines. (A) In response to the combination treatment of CI-994 with etoposide, synergistic effects were observed and inhibited the growth potential of all AT/RT cells in a dose-dependent manner. (B, C) The combination treatment of CI-994 with cisplatin or 4 HC exerted cell type-specific effects. Synergistic effects were observed in the cells treated with the combination of CI-994 with cisplatin only for SNU.AT/RT-9 cells and in cells treated with the combination of CI-994 with 4-HC for SNU.AT/RT-9 cells and BT-16 cells.